Amidation via DMTMM: A New and Efficient Method for Hyaluronan Biomaterials Preparation

摘要

DMTMM is more efficient than EDC/NHS for ligation of amines to HA in water. Unlike EDC/NHS the reaction does not need accurate pH control to proceed. The advantages of DMTMM activation are particularly useful for the scale-up of preparations from the lab to the industrial scale, which is a critical step for the translation biomaterials in the clinical use.