APPLICATION OF SUSPECT SCREENING APPROACH FOR DETECTION DRUG GLUCURONIDES IN WASTEWATER TREATMENT

摘要

Analysis of polar organic contaminants in wastewaters (WW) usually relies on a target approach which involves commonly the use of reference standards to quantify a set of analytes using low-resolution mass spectrometry (MS). In the case of polar contaminants, this task has been carried out mainly with liquid chromatography instruments coupled to mass spectrometry (LC-MS) generally triple quadrupole instruments, which detect only a limited number of analytes without the possibility of a retrospective analysis of data. In contrast to this classical target analysis, the suspect screening has very good prospects as it involves a more comprehensive overview of the contamination of urban wastewaters and of any other environmental sample of great complexity. The recent introduction of very sensitive high-resolution MS platforms and the development of specific software essential for efficient and automated processing of MS data, has been laid the groundwork to a successful non-targeted analysis. Not only can such data be examined for the presence of any known analyte (using elemental composition, isotope pattern, adducts and fragmentation information as well as chromatographic retention behavior as criteria for compound identification) but reported or predicted metabolites can be included in the databases and will be search in any kind of sample.