Effect of P-Tricalcium phosphate addition on the in vitro degradation of reinforced poly(L-lactic acid)

摘要

PLLA as an example of aliphatic polyester of a-hydroxy acid derivative is the most popular biodegradable biomaterial used for low stress level applications. Some limitations of PLLA usage includes long resorption period and unspecific inflammatory tissue response in the case of high crystallinity polymer due to washing out the crystallites, that in turn will result in prolonged bone fusion or osteolytic reactions. Degradation of the implant, that mechanism is mainly hydrolysis can be tailored by choosing proper molecular weights of the polymer, processing method that may influence material morphology, additives etc. Therefore, composites of PLLA with bioactive ceramics have been widely challenged in order to enhance either mechanical properties, degradation rate and to induce osteoconductive characteristic [1].