Quantitative mass spectrometry shows gender differences in lipid mediators in bronchoalveolar lavage fluid from healthy never-smokers, smoker and COPD patients

摘要

Lipoxygenase acitivity in BALF shows gender-specific regulation in relation to both smoking and disease. The observed shifts were 5-LOX- and 12/15-LOX-specific, with smoking in both genders driving changes in 5-LOX activity whereas 12/15-LOX showed gender-specific regulation in COPD. These findings suggest that distinct lipid mediator biosynthetic pathways evidence unique responses to both disease and smoking. The observed gender-specific component provides potential insight into the gender imbalance in COPD cases and warrants further investigation. This study will be continused with the analysis of other lipid mediators derived from 5 and 12/15-LOX, that are currently.