Structural Analysis of Trace Level Impurities in Drug Substances Using LC/MS/MS Analysis

机译：使用LC / MS / MS分析药物物质中痕量杂质的结构分析

获取原文

获取外文期刊封面目录资料

页面导航

摘要
著录项
引文网络
相似文献
相关主题

摘要

The drug impurity profiles are critical to the safety and potency assessment of the drug candidate for clinical trials. SCH 900518, a successor to boceprevir, is a potent, selective 2nd generation HCV NS3 protease Inhibitor discovered by Schering-Plough. The use of LC/MS(/MS) has a significant impact on unknown characterization1-4. In this study, a rapid and sensitive method was developed for the determination of the trace level impurities in SCH 900518.

机译：药物杂质谱对临床试验的药物候选者的安全性和效力评估至关重要。 Boceprevir的继任者，SCH 900518是由Schering-PLOW发现的有效的选择性第二代HCV NS3蛋白酶抑制剂。 LC / MS（/ MS）的使用对未知表征1-4产生了重大影响。在该研究中，开发了一种快速和敏感的方法，用于测定SCH 900518中的痕量杂质。

著录项

来源
《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2010年||共1页
会议地点
作者
Li-Kang Zhang; Birendra N. Pramanik;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Trace Level Quantification of the (?)2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol Genotoxic Impurity in Efavirenz Drug Substance and Drug Product Using LC–MS/MS [J] . Nagadeep Jaishetty, Kamaraj Palanisamy, Arthanareeswari Maruthapillai, Scientia pharmaceutica . 2016,第3期

机译：液相色谱法测定依法韦仑药物和药品中（？）2-（2-氨基-5-氯苯基）-4-环丙基-1,1,1-三氟-3-丁炔-2-醇遗传毒性杂质的痕量定量–MS / MS
2. A SELECTIVE AND SENSITIVE METHOD DEVELOPMENT AND VALIDATION BY LC–MS/MS APPROACH FOR TRACE LEVEL QUANTIFICATION OF THREE POTENTIAL GENOTOXIC IMPURITIES IN PANTOPRAZOLE SODIUM DRUG SUBSTANCE [J] . Nelaturi Subbaiah, Gopi Reddy Venkata Subba Reddy, Nitesh Kanyawar, Rasayan Journal of Chemistry . 2017,第4期

机译：LC-MS / MS方法选择性灵敏的开发和验证，用于痕量定量潘托唑钠药物中三种潜在的遗传氧化杂质
3. DETERMINATION OF TRACEABLE GENOTOXIC IMPURITY CHLOROACETYL CHLORIDE A CARCINOGEN BY LC/MS/MS IN DRUG SUBSTANCES [J] . Natarajan Sivanadham, Kempegowda Bk, Bharathiar M Asian Journal of Pharmaceutical and Clinical Research . 2016,第2期

机译：LC / MS / MS法测定药物中痕量可遗传的遗传毒性杂质氯乙酰氯的致癌性
4. Structural Analysis of Trace Level Impurities in Drug Substances Using LC/MS/MS Analysis [C] . Li-Kang Zhang, Birendra N. Pramanik American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用LC / MS / MS分析药物物质中痕量杂质的结构分析
5. LC-MS/MS Quantitative Method for Trace Analysis of Pesticides in Urban/Suburban Water Wells in Milwaukee, Ozaukee, Washington, and Waukesha Counties in Wisconsin [D] . Trujillo, Dulay Manuel. 2021

机译：LC-MS / MS在Milwaukee，Ozaukee，华盛顿和威斯康星州乌沙科河井中的杀虫剂踪影分析的定量方法
6. Trace Level Quantification of the (−)2-(2-amino-5-chlorophenyl)-4-cyclopropyl-111-trifluoro-3-butyn-2-ol Genotoxic Impurity in Efavirenz Drug Substance and Drug Product Using LC–MS/MS [O] . Nagadeep Jaishetty, Kamaraj Palanisamy, Arthanareeswari Maruthapillai, 2016

机译：使用LC对痕量定量的依法韦仑药物和药品中的（-）2-（2-氨基-5-氯苯基）-4-环丙基-111-三氟-3-丁炔-2-醇基因毒性杂质–MS / MS
7. A Selective and Sensitive Method Development and Validation by LC-MS/MS Approach for Trace Level Quantification of Potential Genotoxic Impurities of ERL Ethyl Ester and ERL Nitro Compound in Erlotinib Hydrochloride Drug Substance [O] . Nelaturi Subbaiah, Gopireddy Venkata Subba Reddy 2017

机译：LC-MS / MS方法的选择性和敏感方法开发和验证用于欧尔乙酯和ERL硝基化合物的潜在遗传毒性杂质，奥尔洛替尼盐酸盐药物物质
8. Metabolomic Analysis of the Secretome of Human Embryonic Stem Cells Following Methyl Parathion and Methyl Paraoxon Exposure. Phase 3. LC-MS-MS Structural Confirmation. [R] . Madren-Whalley, J. S., Sekowski, J. W., Palmer, J. A., 2014

机译：甲基对硫磷和甲基对氧磷暴露后人胚胎干细胞分泌组的代谢组学分析。阶段3.LC-ms-ms结构确认。

Structural Analysis of Trace Level Impurities in Drug Substances Using LC/MS/MS Analysis

摘要

著录项

引文网络

相似文献

相关主题

期刊订阅