An LC-ESI-MS/MS Targeted Metabolomics Approach for Discovery of Biological Activity

摘要

Uncover the biological activity and mechanisms of action of the prenylflavonoid xanthohumol in normal and lipopolysaccharide (LPS) activated human THP-1 cells. Xanthohumol is specific to hops and has been shown to have a wide range of biological activity: (1) Antigenotoxic; (2) Antimutagenic; (3) Anti-inflammatory. Xanthohumol mechanisms of action remain largely unknown.