IMPROVEMENT OF AUTOANTIBODY DETECTION IN AUTOIMMUNE DISEASES BY INNOVATIVE SOLID-PHASE GLYCOPEPTIDE BASED TECHNOLOGIES

摘要

Measurement of a variety of disease specific biomarkers, such as antibodies, is an important tool for the diagnosis, the follow-up and future prevention of specific autoimmune diseases. In fact, sera from patients suffering from autoimmune disorders often contain multiple types of autoantibodies. Some autoantibodies can be exclusive of a disease and thus used as biomarkers for diagnosis; others fluctuate with disease exacerbations or remissions and are extremely valuable in the follow up of patients. In this scenario, identification of autoantibodies, as disease biomarkers, should be achieved using native antigens in simple biological assays. The role and predictive value of antibodies has been demonstrated in our laboratory in the field of Multiple Sclerosis.