A CASE STUDY FOR DEMONSTRATING THE USEFULNESS OF IMAGING MASS SPECTROMETRY IN TOXICITY ASSESSMENT USING AN AMIODARONE-INDUCED PHOSPHOLIPIDOSIS MODEL

摘要

Investigating the local distribution of drug and biomarker in target organs provides useful information, which accelerates drug discovery and development. Imaging mass spectrometry (IMS) is a powerful technique to detect the localization of compounds of interest in biological tissue without any labeling. In the present report, we demonstrate the utility of IMS to investigate drug and biomarker distribution in an amiodarone-induced phospholipidosis model.