FRAGMENTATION OF OLIGOSACCHARIDES AND SUPPRESSION OF METAL-SALT INDUCED ADDUCTS USING ELECTROSPRAY IONIZATION

摘要

It is known that alkaline adduct-ions influence CID and PD induced fragmentation mechanisms of oligosaccharides [1,2]. For proteins the use of ammonium acetate to counteract cation induced signal suppression in electrospray ionization is published [3]. To increase the intensity of the non-adducted molecular ion the application of ammonium acetate to oligosaccharide containing samples is of interest.