LC-MS/MS ANALYSIS AND RAT PHARMACOKINETICS OF THE NOVEL CYCLIN-DEPENDENT KINASE INHIBITORS BP-14 AND BP-20

摘要

BP-14 and BP-20 are novel cyclin-dependent kinase inhibitors, structurally related to roscovitine, with potent antiproliferative activity [1]. A simple LC-MS/MS method for determining them in biological material was developed and validated following EMA guidelines. The method was applied in a pharmacokinetic study in rats following i.v. and i.d. administration including plasma pharmacokinetics, tissue distribution and excretion (renal and biliary).