Study by Electrospray Ionization Mass Spectrometry of the Complexation of Histone Deacetilase Inhibitors With Divalent Metal Ions

摘要

Although some generalizations could be made on the type of adducts observed in the MS spectra of SAHA, OHA or VPA in the presence of different metal cations, the spectra were in general characteristic, with the presence of some particular adduct or with a different relative abundance among the formed species. Although the studied HDACIs have the same type of bioactivity, they exhibit a clearly different behavior in the presence of different metals which may help explain their dissimilar enzymatic specificity. The activity of HDACIs has been previously related to the formation of bidentate chelates, but in the present study other species are also formed in high relative abundance.