A new and efficient telescoped process for the synthesis of 3,5-diaryl-1,2,4-thiadiazoles from arylnitries in ionic liquid

摘要

In terms of chemical efficiency and synthetic step, it would be desirable to expand methodology with using handy substrates. One of the effective strategies for provides this goal is telescoped process. Such methodology is of great importance for industrial processes as a result of the (i) impact on the throughput, (ii) implication of less toxic solvents and, thus, a more environmentally friendly process, and (iii) lack of material loss as a result of intermediate product workup, and so on. So, designing of synthetic process through this manner is highly demand. 1,2,4-Thiadiazole nucleus constitute the core units of many natural products. Although currently the only commercial 1,2,4-thiadiazole drug is the antibiotic cefozopram, there are a number of synthetic products related to this system with a broad range of biological activities. The most well-known method for the preparation of these compounds limited to thioamides as precursors. Therefore, expansion of this method to a number of substrates for the preparation of new 3,5-diaryl-1,2,4-thiadiazole derivatives, is highly desirable.