Identification of Urinary Protein Biomarkers for Diagnosis of Hepatocellular Carcinoma by an Onco-proteogenomics Approach

摘要

Hepatocellular carcinoma (HCC), the major type of liver cancer, is among the most lethal cancers owing to its aggressive nature and frequently late detection. The possibility to identify early diagnostic biomarkers could be of significant benefit for this type of liver cancer treatment. Advances in gene-expression profiling technologies have enabled the molecular classification of HCCs into defined subclasses, forming a firm basis on which to build more informative clinical trials. To link cancer proteomics to genomics and transcriptomics, we have employed onco-proteogenomics as an integrated research approach to explore protein expression profiles in urine from HCC patients and normal controls in order to detect tumor-specific biomarkers for HCC.