Identification of Grp78/BiP Protein Complexes Using Affinity Mass Spectrometry

摘要

Optimization of affinity mass spectrometry strategy and identification of Grp78/BiP protein-protein interactions in skeletal muscle of wild type and ALS mice. Grp78/BiP and SERCA1 interaction is critical to preserve SERCA1 function in skeletal muscle (2). Grp78/BiP interact with non-ER proteins in ALS, indicating translocation of Grp78/BiP under ER stress conditions (3).