Evaluation of a Universal LC-MS/MS Assay for Bioanalysis of Human IgG4 Subclass Monoclonal Antibody Protein Drugs

机译：对人IgG4亚克类单克隆抗体蛋白药物生物分析的通用LC-MS / MS测定的评价

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Development and evaluation of an exploratory universal IgG4 clinical LC-MS/MS assay Reliability evaluation of the assay: quantitative comparison with a confirmatory surrogate peptide.

机译：探索性通用IGG4临床LC-MS / MS测定的开发和评估试验的可靠性评估：与确认替代肽的定量比较。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2014年||共1页
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Craig Titsch; Hao Jiang; Weifeng Xu; Jianing Zeng; Michael Furlong; Anne-Francoise Aubry; Mark E. Arnold;
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入库时间 2022-08-20 20:04:17

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1. A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies [J] . FurlongM.T., OuyangZ., WuS., Biomedical Chromatography: An International Journal Devoted to Research in Chromatographic Methodologies and Their Applications in the Biosciences . 2012,第8期

机译：一种通用替代肽，可在临床前动物研究中对多种人类单克隆抗体和人类Fc融合蛋白候选药物进行LC-MS / MS生物分析
2. An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies [J] . FurlongM.T., TitschC., XuW., Bioanalysis . 2014,第13期

机译：探索性通用LC-MS / MS测定法用于临床研究中铰链区稳定的人IgG4 mAb的生物分析
3. Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates [J] . Voronin Kimberly, Allentoff Alban J., Bonacorsi Samuel J. Jr., Journal of Labelled Compounds and Radiopharmaceuticals . 2014,第9期

机译：稳定同位素标记的通用替代肽的合成，用作人IgG和Fc融合蛋白候选药物的LC-MS / MS生物分析中的内标
4. Evaluation of a Universal LC-MS/MS Assay for Bioanalysis of Human IgG4 Subclass Monoclonal Antibody Protein Drugs [C] . Craig Titsch, Hao Jiang, Weifeng Xu, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：对人IgG4亚克类单克隆抗体蛋白药物生物分析的通用LC-MS / MS测定的评价
5. Development of a monoclonal antibody-based antigen detection enzyme-linked immunosorbent assay (ELISA) for the diagnosis of human toxoplasmosis. [D] . Grushka, Daniel. 2001

机译：基于单克隆抗体的抗原检测酶联免疫吸附测定（ELISA）的开发，用于诊断人类弓形虫病。
6. Multiplex LC-MS/MS Assays for Clinical Bioanalysis of MEDI4276 an Antibody-Drug Conjugate of Tubulysin Analogue Attached via Cleavable Linker to a Biparatopic Humanized Antibody against HER-2 [O] . Morse Faria, Marlking Peay, Brandon Lam, 2019

机译：用于医学生物学分析的MEDI4276的多重LC-MS / MS分析MEDI4276是一种通过可切割接头连接至抗HER-2双原位人源化抗体的Tubulysin类似物的抗体-药物偶联物
7. Selection of Monoclonal Antibodies Against 6-oxo-M1dG and Their Use in an LC-MS/MS Assay for the Presence of 6-oxo-M1dG in Vivo [O] . Akingbade, Dapo, Kingsley, Philip J., Shuck, Sarah C., 2012

机译：单克隆的选择抗6-oxo-M1dG的抗体及其在LC-MS / MS中的用途存在的测定体内6-氧代-M1dG
8. Use of Monoclonal Antibodies to Quantify Subclasses of Human IgG. 1. Development of Two-Site Immunoenzymometric Assays for Total IgG Subclass Determinations [R] . Hussain, R., Poindexter, R. W., Wistar, R., 1986

机译：使用单克隆抗体来量化人IgG的亚类。 1.开发用于总IgG亚类测定的双位点免疫酶测定法

Evaluation of a Universal LC-MS/MS Assay for Bioanalysis of Human IgG4 Subclass Monoclonal Antibody Protein Drugs

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