A Synthesis of Newly Designed Polymer-supported Chiral Catalyst and Its Application to Highly Stereoselective Asymmetric Cyclopropanation Reactions

摘要

Immobilization of catalysts presented many advantages in the field of asymmetric synthesis in the past decades, such as easy separation, efficient recycling, minimization of metal traces in the product, and an improved handling and process control, that finally result in overall lower costs are well known. Furthermore, in some cases heterogeneous catalysts are even more selective than their homogeneous counterparts. In this regard the development of new heterogeneous catalysts to promote enantioselective organic reactions is an area of great interest Covalent immobilization of homogeneous catalysts to insoluble polymer has received considerable attention in recent years. We report herein the synthesis of newly designed polymer-supported chiral Ru(II)-phenyloxazoline (pheox).