Synthesis of Perfluoroalkylated Benzenes and Pyridines through Cationic Rh(I)/Modified-BINAP-Catalyzed Chemo- and Regioselective 2 + 2 + 2 Cycloaddition

摘要

Perfluoroalkylated aromatic compounds are important building blocks for the synthesis of various catalysts,reagents,and substrates used for fluorous chemistry,so the development of their convenient synthetic methods is highly desired.The most frequently employed regioselective method is a Cu-mediated cross-coupling reaction of perfluoroalkyl iodides and aryl halides developed by McLoughlin and Thrower.However,this method requires harsh reaction conditions,excess Cu-reagents,and regioselective preparation of the aryl halides.