Ruthenium Hydride-Catalyzed Regioselective Addition of Aldehydes to Dienes Leading to beta,gamma-Unsaturated Ketones

摘要

The transition-metal-catalyzed carbon-carbon bond forming reactions have found a plenty of applications in organic synthesis.Ruthenium catalysts have contributed to this area with many useful transformations.We recently reported that the regioselective addition of aldehydes to unsaturated ketones was effectively catalyzed by RuHCl(CO)(PPh3)3 (the first equation of Scheme 1).