Combining MIAX-Based In-Silico-Peptide-Chips with Membrane-Support Peptide-Array-Chips Oriented to Novel Drug Discovery

摘要

Protein-protein interactions and polypeptide interaction in general play a central role in molecular recognition processes relevant to several cellular functions and triggering a diversity of biochemical processes, all of them at the realm of the natural, life sustaining endeavor. Moreover, unveiling disease generating mechanisms at the molecular level as well as the search for new chemical compounds to mimic, inhibit, or enhance determined molecular functions make knowledge of the principles governing polypeptide interaction crucial. While data from large scale genome analysis projects are accumulating at high rates, tools for their rational analysis leading to reveal the principles governing polypeptide interactions have just started to be explored. Nevertheless, because of the intricacy of the problem which involves the yet completely solved problem of polypeptide 3D structure prediction and protein folding as well as consideration of the environment and conditions under which the interactions occur, approaching the problem requires both theoretical and experimental tools to deal with its intrinsic combinatorial chemical nature.