Helical net plots and surface lipophilicity mapping of transmembrane helices of integral membrane proteins:aids to 3D structure determination of integral membrane proteins

摘要

Many transmembrane (TM) proteins possess several alpha helices arranged in a helix bundle.In this case several questions important for any integral membrane protein should be answered,namely:1) how the individual helix-helix interact between each other (i.e.which helix surface interacts with which surface of a second helix;2) which helix residues interact with fatty amino acid chains of the phospholipids within the bilayer.