Structure-activity relationship studies of new cyclic MSH analogues using cloned-human melanocortin receptors lead to greater selectivity and inverse agonists

摘要

Melanotropics are peptides derived through a series of proteolytic cleavages from the precusor protein pro-opiomelanocortin.These melanotropin peptides are known to have a broad spectrum of physiological actions including regulation of pigmentation,thermoregulation,regulation of feeding behavior and erectile dysfunction.