Orally Administered Sub-Antimicrobial Doxycycline Attains Synovial Fluid Levels Capable of Inhibiting Matrix Metalloproteinases 3 and 13

摘要

This study confirms that intragastric administration of low-dose doxycycline results in measurable synovial-fluid doxycycline concentrations; this may decrease cartilage catabolism through inhibition of matrix metalloproteinases and may slow the progression of osteoarthritis. Tetracyclines have been used to alleviate symptoms and slow the progression of osteoarthritis (OA). In vitro studies indicate that doxycycline at concentrations of 0.0462 (jig/ml significantly decreases matrix metalloproteinases(MMPs) 3 and MMP-13 gene expression in synoviocytes treated with either inter-leukin-1 or MMP-13. The purpose of this study was to determine if low-dose doxycyclinea administered orally could achieve anti-MMP concentrations in synovia! fluid and plasma.