Comparison of bioavilability of chitosan tablet formulation of pentoxifylline with a commercial product(trental~direct R)

摘要

Pentoxifylline(PX) in an orally active hemorheological aent for the treatment of intermittent claudication or oterh circulatory disorders. PX is rapidly absorbed from the gastrointestinal tract and also rapidly metabolised. Administration of single doses (400 mg) of a PX extended-release tablets results in t_max values of 2-4 hours, mean C_max values of 55-300 ng/mL. The absolute bioavailability was estimated as 33