Potential-dependent Characterization of Bombesin Adsorbed on Roughened Ag, Au, and Cu Electrode Surfaces

摘要

Cancer is a class of progressive diseases in which a group of cells display uncontrolled growth, invasion, and sometimes migration to other locations in the body via the lymph or blood! The variation among individual cancers is usually affected by complex interactions between carcinogens and the host genome. One of the host genome agents is bombesin (BN, pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-GlyHis-Leu-Met-NH2), an endogenous neurotransmitter that affects a broad range of physiological responses,2-4 including stimulation of the growth of androgen-independent cancer cells (i.e. small cell lung, glioblastoma, gastric, pancreatic, prostate, breast, and colon cancers),5-7 by expressing four classes of functional receptors belonging to the G protein-coupled superfamily with seven transmembranespanning regions. This makes these receptors potential receptor-positive cancer markers in early diagnosis and molecular targets for the detection of lesions in which they are expressed. However, the mechanism of BN tumor growth-stimulating effects for each of the four receptors remains unclear.