Bone-grafting of canine extraction sockets with an injectable calcium phosphate biomaterial

摘要

This experimental study evaluated the osteoconduction properties of an injectable bone substitute (IBS) composed of a polymeric carrier and a calcium phosphate mineral phase, which was used to fill mandibular and maxillary canine extraction sockets. The polymer was a cellulosic derivative (methyl-hydroxy-propyl-cellulose, MHPC), and the mineral phase consisted of granules of biphasic calcium phosphate (BCP) ceramics 200 to 500 mu m in diameter. Mandibular and maxillary premolars were extracted from 3 dogs and 60 extraction sites were immediately treated with the IBS or left unfilled as control sites. Three months after implantation, histological studies showed that the IBS was able to support the extensive apposition of well-mineralized newly-formed lamellar bone over the entire socket surface and appeared to prevent alveolar ridge bone loss in treated extraction sites.