Changes in Mechanical Properties and GBR Application of TCP/CPLA Composite

摘要

Mechanical strength changes in vitro and in vivo, and guided-bone-regeneration (GBR) applications of beta -tricalcium phosphate (TCP) / co-polymerized poly-L-lactide (CPLA) composite were examined using physiological saline solution and in vivo studies conducted using beagles. Mechanical strength of composites soaked in physiological saline decreased and reached plataue after 4 weeks. Conversely, the CPLA decreased greately in strength afgter 4 weeks' soaking. In beagles' subcutaneous tissue, no changes in mechanical properties of the composites and CPLA were observed after 8 weeks. A GBR test using beagles' mandibles and tibias showed excellent regeneration of bone up to 20x10x10 mm~3 for mandibles' and 20 mm in length for tibias' bone defects. These results suggested that the composites keep sufficient mechanical properties in vivo and are applicable as a GBR membrane.