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A Novel Approach towards Biochemical Synthesis on Cyberphysical Digital Microfluidic Biochip

机译:一种新的媒体综合性综合性综合性综合性 - 杂志数码微流体Biochip

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Digital Microfluidic Biochip (DMFB) consists of Two-Dimensional (2-D) microarrays that can perform many diagnostic tests simultaneously. DMFB's are expected to be combined with cyberphysical systems in near future. Thus faster and error-free synthesis techniques need to be implemented on such chips. Synthesis of various bio-protocols is generally performed based on various mixing modules present on the chip. In this work, the concept of such dedicated virtual modules has been eliminated and a novel Module-Less-Synthesis (MLS) method is proposed for accomplishing bio-assays in cyber physical DMFB. We have proposed different directional-shifts (movements) of droplet and computed the percentage of mixing accomplishment for each directional-shift of the droplet. We have also identified various shift-patterns (movements) to accomplish entire mixing in lesser time compared to earlier synthesis methods and also include an error recovery approach for cyberphysical DMFB. Experimental results on real life bioassay like PCR and on synthetic benchmark show improved synthesis performance with bioassay completion time (tmax) significantly reduced from earlier module-based synthesis techniques.
机译:数字微流体Biochip(DMFB)由二维(2-D)微阵列组成,可同时执行许多诊断测试。预计DMFB预计将在不久的将来与网络耳机系统相结合。因此,需要在这种芯片上实现更快和无差错的合成技术。通常基于芯片上存在的各种混合模块进行各种生物协议的合成。在这项工作中,已经消除了这种专用虚拟模块的概念,并且提出了一种新的模块缺点(MLS)方法,用于在网络物理DMFB中完成生物测定。我们已经提出了液滴的不同方向移位(运动),并计算了液滴的每个定向偏移的混合成就的百分比。与早期的合成方法相比,我们还确定了各种换档模式(运动),以在较小的时间内完成整个混合,并且还包括用于网络耳机DMFB的误差恢复方法。实验结果对PCR和合成基准类似的实际生物测量结果表明,从早期的基于模块的合成技术显着降低了生物测定完成时间(TMAX)的改进的合成性能。

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