The Predictability of Pharm-EEG in Patients with Long Unconscious Status

摘要

The main syndrome of severe poisoning is coma. An option of coma outcome is a vegetative state. EEG reactivity due to intravenous benzodiazepines estimates the prognosis for such patients. However, a positive benzodiazepines test has the predictability of about 50-60%. The aim of the work is to assess the role of interaction between gamma amino butyric acid (GABA) and cholinergic systems of the brain. The consequent injections of benzodiazepine and atropine lead to a 20% increase in predictability. The results obtained confirm the following hypothesis. Abnormality of GABA-cholinergic interaction is one of the mechanisms of forming a stable pathological system resulting in the pathogenesis of the vegetative state.