Photochemical Decomposition of Uric Acid Crystals by Ultra-Short Laser Pulses

摘要

In recent years, laser radiation has been proposed as a therapy tool in the medical field (laser therapy). This workpresents the efficiency of a pulsed fiber optic laser in its interaction with synthetic monosodium urate monohydrate(MSUM) crystals, for the management of inflammatory processes and lesions in tissues, muscles and osteoarticularjoints affected by crystalline pathologies. The synthetic monosodium urate crystals were made based on the McCarthymethod. Such samples were exposed to the direct radiation of the laser light source, whose characteristics are as follows:wavelength centered at λ = 1058 nm, pulse width of τ = 13 ns, repetition frequency of f_R = 210 kHz and peak energy ofE_P = 55 nJ. This radiation is absorbed by the tissue, which produces a photochemical interaction at the molecular level inthe crystalline formations. The exposure times were from 7 to 12 minutes, and the best exposure time was presented in12 m. As a result, the photochemical interaction of light with crystals could be observed, resulting in a variation inmolecular structure. Likewise, a decrease in their concentration was found in order to make uric acid crystals, that arewithin the joints or tissues affected by crystalline pathologies, more soluble to be eliminated through the urine, andtherefore, provide at the same time analgesic and anti-inflammatory action in the affected area.