A Simulation Model of Insulin Granule Dynamics in Pancreatic Beta Cell with Module Structure

摘要

Recently, the number of diabetic patients in Asian countries is increasing. While it is considered that impairment of insulin secretioncauses such type-2 diabetes, the mechanism of insulin secretion in pancreatic beta cells is still unclear. In our research, in order tohave a deeper knowledge on the mechanism, simulation-based approach has been adopted.an improved simulation model of insulingranule dynamics is proposed based on bio-imaging data and medical background. The simulation model is composed of three parts(Granule generating, Inner layer and Outer layer). Here, a keynote point is to represent the outer layer by introducing a modulestructure. Through some simulation experiments by using the proposed model, it is confirmed that the results are consistent with themedical knowledge currently obtained.