Evaluation of anticancer agent transport in brain tumors after focused ultrasound-induced blood-brain/blood-tumor barrier disruption

摘要

Blood-brain and blood-tumor barriers (BBB and BTB) constitute a major obstacle to the transport of therapeutics in brain tumors. While several studies have demonstrated the potential of focused ultrasound (FUS) to disrupt transiently the BBB/BTB and improve drug delivery, there is a lack of fundamental understanding of the impact of this method on the pharmacokinetics of anticancer agents in the brain microenvironment. In this study, we examine the impact of FUS-induced BBB/BTB disruption on the transport of two anticancer agent with different properties in a model of breast cancer brain metastases using experimental measurements and drug transport mathematical modeling.