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Wogonin, a Plant Flavone, Potentiates Etoposide-Induced Apoptosis in Cancer Cells

机译:Wogonin,一种植物黄酮,增强依托泊苷诱导的癌细胞凋亡。

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Etoposide, a podophylotoxin anticancer agent, induces apop totic cell death in normal and cancer cells. Etoposide-induced apoptosis plays a role in not only anticancer effect but also adverse reaction, such as myelosuppression. Since we have found that wogonin, a flavone found in Scutellaria baicalensis Georgi, prevents thymocyte apoptosis induced by various compounds including etoposide, we examined the effect of this flavone on etoposide-induced apoptosis in cancer cells. Although 100 μM wogonin itself significantly increased DNA fragmentation in HL-60 cells, this change was not observed in Jurkat cells. On the other hand, this flavone significantly potentiated etoposide-induced apoptosis in Jurkat and HL-60 cells. Similarly, wogonin accelerated etoposide-induced cell death in lung cancer cells. Since wogonin had no effect on the action of other anticancer agents, such as 5-FU and cisplatin, this flavone seems to accelerate only etoposide-induced apoptotic cell death in cancer cells. These results suggest that the modification of etoposide-induced apop tosis by wogonin may be available to reduce the adverse reaction of this agent.
机译:鬼臼毒素,一种鬼臼毒素抗癌剂,可诱导正常细胞和癌细胞中凋亡细胞的死亡。依托泊苷诱导的细胞凋亡不仅在抗癌作用中起作用,而且在诸如骨髓抑制的不良反应中也起作用。由于我们发现wogonin(一种在黄cut中发现的黄酮)可阻止由多种化合物(包括依托泊苷)诱导的胸腺细胞凋亡,因此我们研究了该黄酮对依托泊苷诱导的癌细胞凋亡的作用。尽管100μMwogonin本身可显着增加HL-60细胞的DNA片段,但在Jurkat细胞中未观察到这种变化。另一方面,这种黄酮能显着增强依托泊苷诱导的Jurkat和HL-60细胞凋亡。同样地,伍格宁加速了依托泊苷诱导的肺癌细胞死亡。由于沃戈宁对其他抗癌药(例如5-FU和顺铂)的作用没有影响,因此这种黄酮似乎仅加速依托泊苷诱导的癌细胞凋亡。这些结果表明,沃戈宁对依托泊苷诱导的细胞凋亡的调节可用于减少该药物的不良反应。

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