Contrlled release of metoprolol: influence of motility and food

摘要

Food effect and gastric motility are important factors for oral drug absorption~1. Gastric emptying determines the onset of the pharmacokinetics and food impacts gastric emptying and the absorption process for many drugs. Metoprolol was chosen as high permeability model drug~2 to investigate the influence of food and gastric motility pattern on the absorption and the pharmacokinetics of a MR dosage form. A commercially available controlled release tablet (CR) was tested. The rug was administered in fasted and fed state to mongrel dogs. The gastric motility was monitored using a pneumohydraulic manometric system. The objective of this work was to investigate if there is a correlation between the food effect and motility pattern on the absorption rate of the controlled release of the dosage form.