ROS-responsive drug carriers for intracellular delivery of pro-oxidant drugs

机译：ROS响应性药物载体，用于细胞内递送抗氧化剂药物

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ROS-responsive thioether-bearing polymer was synthesized and used for the intracellular delivery of PL. PL-loaded TEP NPs were fabricated by w/o/w double nanoemulsion method. PL-TEP NPs showed a ROS-sensitive drug release profile due to ROS-triggered oxidation of thioether groups of the TEP. PL-TEP NPs showed cancer-selective cytotoxicity over normal hDFB cells because PL selectively increased the level of intracellular ROS in cancer cells.

机译：合成了ROS-反应性的含硫醚的聚合物，并将其用于PL的细胞内递送。通过w / o / w双纳米乳液法制备了PL负载的TEP NP。 PL-TEP NPs显示出ROS敏感的药物释放曲线，这是由于ROS触发了TEP的硫醚基团的氧化。 PL-TEP NPs对正常hDFB细胞显示出癌症选择性的细胞毒性，因为PL选择性地增加了癌细胞中细胞内ROS的水平。

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《Society for Biomaterials annual meeting and exposition》|2019年|528-528|共1页
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Yoon-Seok Kim; Sumin Kim; Dae Gun Choi; Min Suk Shim;
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2. A Biodegradable and Amphiphilic Linear-Dendritic Copolymer as a Drug Carrier Platform for Intracellular Drug Delivery [J] . Wang Haibo, Wu Yan, Liu Gongyan, Macromolecular chemistry and physics . 2016,第18期

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4. ROS-responsive drug carriers for intracellular delivery of pro-oxidant drugs [C] . Yoon-Seok Kim, Sumin Kim, Dae Gun Choi, Society for Biomaterials annual meeting and exposition . 2019

机译：ROS响应药物载体，用于细胞内递送促氧化物药物
5. Non-invasive label-free imaging of sub-cellular architecture and intracellular behavior of nano-drug-delivery carriers using Raman micro-spectroscopy. [D] . Chernenko, Tatyana. 2010

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8. Peptides for Specific Intracellular Delivery and Targeting of Nanoparticles: Implications for Developing Nanoparticle-Mediated Drug Delivery [R] . 2010

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ROS-responsive drug carriers for intracellular delivery of pro-oxidant drugs

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