Transglutaminase Crosslinking of Resilin-based Proteins for Vascular Applications

摘要

Conclusions: Transglutaminase crosslinking created hydrogels suitable for long-term cell adhesion and culture. Varying the hydrogel stiffness modulated hMSC spreading and endothelial function of cells. The stiffest matrices increased cell spreading and endothelial function. Overall, our tunable hydrogel system is a promising tool for vascular applications and provides mechanical environments that more closely mimic native subendothelial environments compared to conventional culture substrates.