Conclusion: Nanoparticles may form the basis of an optimal vaccine formulation for malaria TBVs. Fine-tuning size, as a parameter for nanoparticle-based delivery platforms, is a promising avenue for improved control over lymphatic kinetics - an important consideration for vaccine/therapeutic applications that extend well beyond the transmission blocking vaccine platform. In this biodegradable, PEG-PLGA nanoparticle TBV delivery system, size was found to be a key-determining factor for lymph node trafficking, retention, and uptake by antigen presenting cells. The insights gained by this study will have broader impacts on the design of vaccines beyond the malaria paradigm.
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