Locally Administered Lovastatin-Encapsulating Poly(lactic-co-glycolic) Acid Nanoparticles Protect Against #Experimental Autoimmune Neuritis

摘要

Conclusions: We hypothesize that lovastatin-encapsulating NPs protect against EAN by locally disrupting GTPase activation and leukocyte trafficking. The use of biodegradable lovastatin-encapsulating NPs offers the advantage of a non-systemic, non-surgical delivery strategy with which to better treat inflammatory peripheral nerve disorders. Future studies will determine the therapeutic potential of these findings.