Stimuli sensitive polyurethane-based hydrogels for the controlled and triggered release of anti-inflammatory drugs and anti-bacterial ions

摘要

Conclusions: A platform of reverse thermo-responsive, cytocompatible polymeric systems was successfully developed starting from custom-made PUs based on Poloxamer P407, an aliphatic non-toxic diisocyanate and a commercially available diol, overcoming some of Poloxamer gel drawbacks. The developed hydrogels showed a fast sol-to-gel transition in physiological conditions and promising properties for tissue engineering as delivery systems. Moreover, the pH of the surrounding environment was proven to be a smart stimulus to finely tune the release kinetics of previously encapsulated antiinflammatory drugs or antibacterial ions.