Woven Electrochemically Aligned Collagen Scaffold Guides Tenogenesis of Mesenchymal Stem Cells

摘要

Electrochemically aligned collagen threads can be woven in a 3D scaffold form whose mechanical behavior converges to that of the real tendon in terms of strength, stiffness, toe-in region and extensibility. The earlier observations on the tenoinductive effect of ELAC at the expression level is confirmed by the present results at the matrix synthesis level. Attaining tenoinduction without using growth factors and on a mechanical competent platform renders this woven scaffold concept a promising candidate for tendon tissue engineering.