Synthesis of Solid Lipid Nanoparticles and their Interaction with Skin

摘要

The main conclusions of this study are: (1) the PIT method is a versatile method with which to synthesize SLNs with ultra-small sizes and low polydispersity and (2) the interaction of the loading compounds with skin depends strongly on the compound chemistry. The DOE analysis showed that dye solubility, dye polarity, and latent heat of melting were the most significant parameters effecting particle interactions with skin. Overall, we conclude that when using this method, it is possible to consistently produce SLNs with particle diameters less than 20 nm and low polydispersity, almost regardless of synthesis conditions or payload.