The research on the relationship between adrenergic receptor subtypes

摘要

The adrenergic receptors, which control the regulation of blood pressure, energy homeostasis and metabolism of glucose and lipids within the body, are a class of G protein-coupled receptors and a class of the most important receptors within the body. Adrenergic receptors are grouped into three types, α{sub}1, α{sub}2 and β. Within each type, Molecular biological studies revealed further subtypes, they are designated as α{sub}(1A), α{sub}(1B), α{sub}(1D), α{sub}(2A), α{sub}(2B), α{sub}(2D), β{sub}1, β{sub}2, β{sub}3. Biological studies found that some subtypes interact with others in certain tissues, which means there are relations between these subtypes. Currently there have been fewer reports about the relationship between adrenergic receptor subtypes with a lack of selective agonists. Here we use bioinformatics tools and strategies to study the relationship between adrenergic receptor subtypes from three aspects, including molecular evolution, sequence similarity and protein-protein interaction. Finally we find that within the α{sub}1 three subtypes the evolution distance between α{sub}(1A) and α{sub}(1B) is relatively nearer, and their sequence similarity is higher; within the α{sub}2 three subtypes he evolution distance between α{sub}(2A) and α{sub}(2C) is relatively nearer, and their sequence similarity is higher. From the protein-protein aspect we find that α{sub}(1A) is directly interacting with β{sub}1, the three subtypes of α{sub}1 as well as β{sub}2 have more interacting proteins, and hence they are more active within the body.