An Incremental Linear Programming Based Tool for Analyzing Gene Expression Data

摘要

The availability of large volumes of gene expression data from microarray analysis (cDNA and oligonucleotide) has opened a new door to the diagnoses and treatments of various diseases based on gene expression profiling. In this paper, we discuss a new profiling tool based on linear programming. Given gene expression data from two subclasses of the same disease (e.g. leukemia), we are able to determine efficiently if the samples are linearly separable with respect to triplets of genes. This was left as an open problem in an earlier study that considered only pairs of genes as linear separators. Our tool comes in two versions - offline and incremental. Tests show that the incremental version is markedly more efficient than the offline one. This paper also introduces a gene selection strategy that exploits the class distinction property of a gene by separability test by pairs and triplets. We applied our gene selection strategy to 4 publicly available gene-expression data sets. Our experiments show that gene spaces generated by our method achieves similar or even better classification accuracy than the gene spaces generated by t-values, FCS(Fisher Criterion Score) and SAM(Significance Analysis of Microar-rays).