Nanobiodevice based single molecule and cell sensing for cancer diagnosis and in vivo imaging for stem cell therapy

摘要

Nanobiodevices are developed to analyze biomolecules and cells for genome and proteome analysis. In this article, I will describe numerous advantages of nanobiodivces, especially in the biological, medical, and clinical applications I also describe the development of nanopillar device for the ultrafast separation of DNA and nanoball materials for the fast separation of wide range of DNA fragments. I developed new synthetic method of quantum dots (QDs) based on the appropriate cluster confirmation by the ab initio molecular orbital calculation. QDs are applied to in vivo imaging of stem cell for stem cell therapy and the theranostic device for cancer diagnosis and therapy. Because of the high efficiency of nanobiodevice in the biomolecular and cellular analysis, numerous types of nanobiodevices are developed and applied to the diagnosis of diseases, including cancer, diabetes, hypertension, and infection diseases.