Engineered Matrix Mimetics Support Assembly of Two Distinct Forms of Fibronectin Matrix

摘要

FN matrix mimetics promote cell growth, spreading, migration and contractility. Here we show that growth-promoting matrix mimetics lacking FNIII9 support cell-mediated assembly of either a DOC-insoluble or DOC-soluble matrix. The ease of production of our small FN matrix mimetics, coupled with their ability to regulate the assembly of ECM FN, make them promising candidates for incorporation into tissue scaffolds to promote wound repair.