Study on Herbicidal Activity in Vitro Exposed to Naphthoquinones Photoinhibition of 1,4-Naphthoquione Derivatives

摘要

In this paper, the photoinhibition of four naphthoquinone compounds including Atovaquone, Buparvaquone, Menadione and 2-hydroxy-l,4naphthoquinone were determined. And the preliminary study on the influencing factors and the mechanism of photoinhibition was performed based on some molecular descriptors calculated by the quantum chemistry calculation. The results showed that the inhibitions of Hill activity by four 1,4-naphthoquinone compounds presented the same trends and dose-effect relationships. Among them, Buparvaquone had the highest inhibitory activity. The structure-activity relationship (SAR) analysis indicated that ELUMO might be one of main factors affecting the inhibition of Hill activity by the chemicals having the similar structures with these compounds we tested. At the same time, the lipid/water partition coefficient (logP) and the diameter (Dia) of molecule were also the influencing factors.