Preparation and characterization of Poly-(N, N-dimethyl amino) ethyl methacrylate/Poly (vinyl alcohol) Semi-Interpenetrating (Semi-IPN) Hydrogel

摘要

@@Object to prepare thermo-sensitive and pH-sensitive intelligent hydrogels. The phase transition temperature of different components hydrogels were studied by using UV-VIS spectrophotometer at λ=550nm. Further more, swelling ratios were investigated at different temperature and pH value. This research would provide research foundation for drug delivery system. INTRODUCTION Controlled drug delivery systems via targeted drug delivery of a predetermined dose over a sustained period have been used to overcome the shortcomings of conventional dosage forms [1]. This is because the controlled drug delivery system can provide sustained therapeutic level of drug concentration without toxicity. Drug delivery technology also provides convenience for patients. It would be more beneficial and ideal if a device that would respond to physiopathological signals from an underling disease could deliver the drug. The correct amount of drug would be released upon the stimulation of such a physiopathological signal.