Preparation of Irisquinone Hydroxypropyl-beta-Cyclodextrin Inclusion Complex and Its Thermodynamic Stability

摘要

The inclusion complex formation of irisquinone with hydroxypropyl-beta-cyclodextrin(HP-beta-CD) and the physico- chemical properties were studied. Complex of host molecules with irisquinoe was studied by x-ray diffraction (XRD) and differential scanning calorimetry(DSC). The quantitative analysis with uv-vis indicated that HP-beta-CD could increase the solubility of irisquinone, where the best results was given with HP-beta-CD :irisquinone 2:1 molar ratio. The binding constants of inclusion complex formulation were obtained with relative Higuchi Principle and thermodynamics equation.