Combination of intestinal goblet HT29 and M-like cells with absorptive Caco-2cells to predict oral absorption of nanoparticles containing insulin

摘要

The in vitro permeability assays aim toreproduce the in vivo absorption. Hence, thesystem involving Caco-2/HT-29 and Caco-2/Raji co-culture is used in different proportionsto study the oral bioavailability of insulin. Itsencapsulation into chitosan-coated solid lipidnanoparticles revealed promising.