Development of an In-Vitro Dissolution Model for Prediction of In-Vivo Absorption of Poorly Water Soluble Drugs

摘要

The objective of this study was to develop an in-vitro dissolution model that can simulate the sink condition for poorly water-soluble compounds and predict their in-vivo absorption behaviors. A novel dissolution approach was used. The flow through apparatus (USP 4) was combined with the paddle apparatus (USP2). Solid oral dosage formulations of AMG 517 and other commercial formulations were used to validate the model.