Burst-free and safe depots for therapeutic proteins and peptidesCase study: Sustained release of leuprolide acetate

机译：用于治疗性蛋白质和多肽的安全无爆仓案例研究：醋酸亮丙瑞林的持续释放

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We have developed a liposomal depot system fortherapeutic peptides and proteins. The functionality of thedepot system in vivo was successfully shown by usingleuprolide acetate, a therapeutically relevant peptide drug.

机译：我们已经开发了脂质体贮库系统，用于治疗性肽和蛋白质。的功能通过成功显示了体内的仓库系统醋酸亮丙瑞林，一种与治疗有关的肽药物。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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S. Lutz; K. Kohla; S. Panzner;
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正文语种
中图分类药学;
关键词
depot; leuprolide; proteins; encapsulationsustained release;

机译：仓库;亮丙瑞林;蛋白质封装持续释放;
入库时间 2022-08-26 14:53:51

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1. Effectiveness, pharmacokinetics, and safety of a new sustained-release leuprolide acetate 3.75-mg depot formulation for testosterone suppression in patients with prostate cancer: a Phase III, open-label, international multicenter study. [J] . Marberger M, Kaisary AV, Shore ND, Clinical therapeutics . 2010,第4期

机译：新型缓释醋酸亮丙瑞林3.75 mg储库制剂在前列腺癌患者中抑制睾丸激素的有效性，药代动力学和安全性：一项III期，开放标签，国际多中心研究。
2. The pharmacokinetics and pharmacodynamics of a new sustained-release leuprolide acetate depot compared to market references. [J] . Leitner JM, Mayr FB, Spiel AO, International journal of clinical pharmacology and therapeutics . 2008,第8期

机译：与市场参考相比，新型缓释醋酸亮丙瑞林长效制剂的药代动力学和药效学。
3. A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1273 patients [J] . Ulf W Tunn BMC Urology . 2011,第1期

机译：醋酸亮丙瑞林的6个月长效制剂在日常临床实践中是安全有效的：一项针对1273名患者的非干预性前瞻性研究
4. Sustained-Release of Therapeutic Proteins from Multilayers Adsorbed on the Sidewalls of Porous Membranes [C] . Younghyun Cho, Jinkee Hong, Paula T. Hammond PMSE Symposia . 2012

机译：从多层壁上吸附在多孔膜的侧壁上的多层释放治疗性蛋白质
5. Development, Characterization, and Application of a Biodegradable PEG-Based Delivery Device for the Sustained Release and Biopreservation of Protein Therapeutics [D] . Sheth, Saahil . 2019

机译：基于可生物降解的PEG的递送装置的持续释放和生物保护剂的显影，表征和应用蛋白质治疗剂
6. A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1273 patients [O] . Ulf W Tunn 2011

机译：醋酸亮丙瑞林为期6个月的长效制剂在日常临床实践中是安全有效的：一项针对1273名患者的非干预性前瞻性研究
7. A 6-month depot formulation of leuprolide acetate is safe and effective in daily clinical practice: a non-interventional prospective study in 1273 patients [O] . Tunn Ulf W 2011

机译：醋酸亮丙瑞林为期6个月的长效制剂在日常临床实践中是安全有效的：一项针对1273名患者的非干预性前瞻性研究
8. Effects of Leuprolide Acetate in Depot Suspension on Testosterone Levels, Testicular Size and Semen Production in Male Atlantic Bottlenose Dolphins (Tursiops Truncatus). [R] . Briggs, M. B., VanBonn, W., Linnehan, R. M., 1995

机译：醋酸亮丙瑞林在长效悬浮液中对雄性大西洋宽吻海豚（Tursiops Truncatus）睾丸激素水平，睾丸大小和精液产量的影响。

Burst-free and safe depots for therapeutic proteins and peptidesCase study: Sustained release of leuprolide acetate

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